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Paper Phrog has a minor synergy but at higher Searing Blow levels the increase of damage from this relic is significant.Pen Nib - double damage of Searing Blow but requires some planning to execute.Necronomicon doubles the damage of Searing Blow every time you play it.Wing Boots allows you to take additional campfires that you normally won't be able to get to.
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This gives Flex good synergy with sources of Artifacts, such as Clockwork Souvenir or Panacea A helpful tip with Flex in particular is that if you have an Artifact before you use Flex, or trigger the effect of Orange Pellets after using Flex, you won't lose the Strength gained from it on the next turn.